Hippocampal neural stem cells undergo fate switch following intermittent hypoxia

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Epigenetic mechanisms regulating fate specification of neural stem cells.

Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, hi...

متن کامل

Notch It Up: Nudging Stem Cells toward a Neural Fate

Background: Helicobacter pylori infection is exceptionally prevalent and is considered to be acquired primarily early in life through person-to-person transmission within the family. H. pylori is a genetically diverse bacterial species, which may facilitate adaptation to new hosts and persistence for decades. The present study aimed to explore the genetic diversity of clonal isolates from a mot...

متن کامل

p57kip2 regulates glial fate decision in adult neural stem cells.

Our recent studies revealed p57kip2 as an intrinsic regulator of late gliogenesis and demonstrated that in oligodendroglial precursor cells p57kip2 inhibition leads to accelerated maturation. Adult neural stem cells have been described as a source of glial progenitors; however, the underlying mechanisms of cell fate specification are still poorly understood. Here, we have investigated whether p...

متن کامل

Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells

7 2 ABSTRACT The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or glial cells in separate lineages in the developing CNS. Towards this aim to identify the key molecular determinants for neurogenic...

متن کامل

Physiological and Genomic Consequences of Intermittent Hypoxia Invited Review: Respiratory plasticity following intermittent hypoxia: developmental interactions

physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2019

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.2019.33.1_supplement.551.20